Phospholamban R14del disease: The past, the present and the future

E Vafiadaki, PC Glijnis, PA Doevendans… - Frontiers in …, 2023 - frontiersin.org
Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …

Deciphering the methylation landscape in breast cancer: diagnostic and prognostic biosignatures through automated machine learning

M Panagopoulou, M Karaglani, VG Manolopoulos… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer (BrCa) is characterized by aberrant DNA methylation. We
leveraged high-throughput methylation data from BrCa and normal breast tissues and …

Arena3Dweb: interactive 3D visualization of multilayered networks supporting multiple directional information channels, clustering analysis and application …

M Kokoli, E Karatzas, FA Baltoumas… - NAR Genomics and …, 2023 - academic.oup.com
Arena3Dweb is an interactive web tool that visualizes multi-layered networks in 3D space. In
this update, Arena3Dweb supports directed networks as well as up to nine different types of …

Tissue-specific methylation biosignatures for monitoring diseases: an in silico approach

M Karaglani, M Panagopoulou, I Baltsavia… - International Journal of …, 2022 - mdpi.com
Tissue-specific gene methylation events are key to the pathogenesis of several diseases
and can be utilized for diagnosis and monitoring. Here, we established an in silico pipeline …

A novel blood-based epigenetic biosignature in first-episode schizophrenia patients through automated machine learning

M Karaglani, A Agorastos, M Panagopoulou… - Translational …, 2024 - nature.com
Schizophrenia (SCZ) is a chronic, severe, and complex psychiatric disorder that affects all
aspects of personal functioning. While SCZ has a very strong biological component, there …

The role of apoptotic genes and protein-protein interactions in triple-negative breast cancer

GM Adinew, S Messeha, E Taka… - Cancer Genomics & …, 2023 - cgp.iiarjournals.org
Abstract Background/Aim: Compared to other breast cancer types, triple-negative breast
cancer (TNBC) has historically had few treatment alternatives. Therefore, exploring and …

Neuronal, but not glial, Contactin 2 negatively regulates axon regeneration in the injured adult optic nerve

M Savvaki, G Kafetzis, SI Kaplanis… - European Journal of …, 2021 - Wiley Online Library
Mammalian adult neurons of the central nervous system (CNS) display limited ability to
regrow axons after trauma. The developmental decline in their regenerative ability has been …

[HTML][HTML] BioTextQuest v2. 0: An evolved tool for biomedical literature mining and concept discovery

T Theodosiou, K Vrettos, I Baltsavia… - Computational and …, 2024 - Elsevier
The process of navigating through the landscape of biomedical literature and performing
searches or combining them with bioinformatics analyses can be daunting, considering the …

Using the Allen gene expression atlas of the adult mouse brain to gain further insight into the physiological significance of TAG-1/Contactin-2

I Kalafatakis, K Kalafatakis, A Tsimpolis… - Brain Structure and …, 2020 - Springer
The anatomic gene expression atlas (AGEA) of the adult mouse brain of the Allen Institute
for Brain Science is a transcriptome-based atlas of the adult C57Bl/6 J mouse brain, based …

Prediction and Ranking of Biomarkers Using multiple UniReD

I Baltsavia, T Theodosiou, N Papanikolaou… - International Journal of …, 2022 - mdpi.com
Protein–protein interactions (PPIs) are of key importance for understanding how cells and
organisms function. Thus, in recent decades, many approaches have been developed for …