In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Immune checkpoint inhibitors have revolutionized medical oncology, although currently only
a subset of patients has a response to such treatment. A compelling body of evidence …

Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …

Angiogenesis is defined as the formation of new blood vessels from preexisting vessels and
has been characterized as an essential process for tumor cell proliferation and viability. This …

Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor
initiation and self-renewal capacity and the ability to give rise to bulk populations of …

Tumour angiogenesis is a fast growing domain in tumour biology. Many growth factors and
mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of …

Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in
tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that …

Glioblastoma is one of the most angiogenic human tumours and endothelial proliferation is a
hallmark of the disease. A better understanding of glioblastoma vasculature is needed to …