Portal hypertension, defined as increased pressure in the portal vein, develops as a
consequence of increased intrahepatic vascular resistance due to the dysregulation of liver …

Treatment of older patients with liver disease may require different or longer interventions.
Transplantation of an older liver will be less tolerant of subsequent injury. Future studies are …

Basement membranes provide structural support to epithelium, endothelium, muscles, fat
cells, Schwann cells, and axons. Basement membranes are multifunctional: they modulate …

There is a large interest in developing nanoparticles and extracellular vesicles for delivery of
therapeutics or imaging agents. Regulatory approval of such products requires knowledge …

BACKGROUND & AIMS: Capillarization, characterized by loss of differentiation of liver
sinusoidal endothelial cells (LSECs), precedes the onset of hepatic fibrosis. We investigated …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

The liver sinusoidal endothelial cell (LSEC) forms the fenestrated wall of the hepatic
sinusoid and functions as a control post regulating and surveying the trafficking of molecules …

The porosity of liver sinusoidal endothelial cells (LSEC) ensures bidirectional passive
transport of lipoproteins, drugs and solutes between the liver capillaries and the liver …

Past, present, and future research into hepatic stellate cells (HSCs, also called vitamin A-
storing cells, lipocytes, interstitial cells, fat-storing cells, or Ito cells) are summarized and …

Background Post-hepatectomy liver failure (PHLF) is a major source of morbidity and
mortality in patients undergoing liver resection. The aim of this review is to summarize the …