Acute kidney injury (AKI), a common and serious clinical kidney syndrome with high
incidence and mortality, is caused by multiple pathogenic factors, such as ischemia …

Endothelial dysfunction is characterized by a reduction in nitric oxide generation or an
unbalanced distribution of the relaxing and contracting pressures produced by endothelial …

Rationale: Sepsis is a severe clinical syndrome featured through organ dysfunction due to
infection, while the accompanying acute kidney injury (AKI) is linked to significant incidence …

The management of acute kidney injury (AKI) imposes a significant medical burden. Due to
the lack of effective drug transport vehicles, the administration of therapeutic agents for AKI …

Abstract α-Lipoic acid (α-LA) is a naturally occurring organosulfur component. Oxidative
stress plays an essential role in the pathogenesis of various diseases, such as kidney and …

Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue
oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia …

Sepsis, which is a serious medical condition induced by infection, has been the most
common cause of acute kidney injury (AKI) and is associated with high mortality and …

Background Sepsis-induced acute kidney injury (S-AKI) is an inflammatory disease with sex
differences and there has no effective drugs to cure it. Frehmaglutin D (Fre D) and …

Sepsis-induced multiple organ dysfunction arises from the highly complex pathophysiology
encompassing the interplay of inflammation, oxidative stress, endothelial dysfunction …

ATP and ONOO-play unique roles in various biological events and exhibit notable
interactions. To date, there is no available chemical tool for investigating the correlation …