Efficacy and safety of treatment with omalizumab for chronic spontaneous urticaria: A systematic review for the EAACI Biologicals Guidelines
This systematic review evaluates the efficacy and safety of omalizumab for chronic
spontaneous urticaria (CSU). PubMed, Embase, and Cochrane Library were searched for …
spontaneous urticaria (CSU). PubMed, Embase, and Cochrane Library were searched for …
[HTML][HTML] FcεRI: A master regulator of mast cell functions
Y Nagata, R Suzuki - Cells, 2022 - mdpi.com
Mast cells (MCs) perform multiple functions thought to underlie different manifestations of
allergies. Various aspects of antigens (Ags) and their interactions with immunoglobulin E …
allergies. Various aspects of antigens (Ags) and their interactions with immunoglobulin E …
EAACI Biologicals Guidelines—Recommendations for severe asthma
Severe asthma imposes a significant burden on patients, families and healthcare systems.
Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care …
Management is difficult, due to disease heterogeneity, co‐morbidities, complexity in care …
Chronic spontaneous urticaria: the role and relevance of autoreactivity, autoimmunity, and autoallergy
Chronic spontaneous urticaria (CSU) is a frequent and often severely disabling disease. A
large number of studies were performed during the last 2 decades to clarify its pathogenesis …
large number of studies were performed during the last 2 decades to clarify its pathogenesis …
Co-occurrence of IgE and IgG autoantibodies in patients with chronic spontaneous urticaria
Chronic spontaneous urticaria (CSU) pathogenesis shows a complex and still unclear
interplay between immunoglobulin (Ig) G-and IgE-mediated autoimmunity, leading to mast …
interplay between immunoglobulin (Ig) G-and IgE-mediated autoimmunity, leading to mast …
[HTML][HTML] Biologic drugs in the treatment of chronic inflammatory pulmonary diseases: recent developments and future perspectives
J Plichta, P Kuna, M Panek - Frontiers in Immunology, 2023 - frontiersin.org
Chronic inflammatory diseases of the lung are some of the leading causes of mortality and
significant morbidity worldwide. Despite the tremendous burden these conditions put on …
significant morbidity worldwide. Despite the tremendous burden these conditions put on …
[HTML][HTML] The therapeutic potential for targeting group 2 innate lymphoid cells in asthma
T Matsuyama, H Matsuyama, Y Dotake… - Frontiers in …, 2022 - frontiersin.org
T helper type 2 cells (Th2 cells) and group 2 innate lymphoid cells (ILC2s) play an important
role in the pathophysiology of asthma, including airway eosinophilic inflammation. ILC2s are …
role in the pathophysiology of asthma, including airway eosinophilic inflammation. ILC2s are …
[HTML][HTML] Emerging evidence for pleiotropism of eosinophils
JM Rodrigo-Muñoz, M Gil-Martínez, B Sastre… - International Journal of …, 2021 - mdpi.com
Eosinophils are complex granulocytes with the capacity to react upon diverse stimuli due to
their numerous and variable surface receptors, which allows them to respond in very …
their numerous and variable surface receptors, which allows them to respond in very …
[HTML][HTML] Differential effects of alarmins on human and mouse basophils
AR Gambardella, R Poto, V Tirelli… - Frontiers in …, 2022 - frontiersin.org
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the
pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic …
pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic …
[HTML][HTML] Therapeutical targets in allergic inflammation
From the discovery of IgE to the in-depth characterization of Th2 cells and ILC2, allergic
inflammation has been extensively addressed to find potential therapeutical targets. To date …
inflammation has been extensively addressed to find potential therapeutical targets. To date …