Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Telomere attrition is considered a hallmark of ageing. Untangling the proximate causes of
telomere attrition may therefore reveal important aspects about the ageing process. In a …

The field of stress physiology has rapidly expanded, particularly in those fields interested in
identifying chronic stress in wild animals. Despite this expansion, stress remains difficult to …

Telomeres are DNA structures that protect chromosome ends. However, telomeres shorten
during cell replication and at critically low lengths can reduce cell replicative potential …

Prenatal effects on telomere length are increasingly recognized as a potential contributor to
the developmental origin of health and adult disease. While it is becoming clear that …

Why and how we age are 2 intertwined questions that have fascinated scientists for many
decades. However, attempts to answer these questions remain compartmentalized …

It is well known that oxidative stress is a major cause of DNA damage and telomere attrition.
Most endogenous reactive oxygen species (ROS) are produced in the mitochondria …

Aging is characterized by functional decline occurring alongside changes to several
hallmarks of aging. One of the hallmarks includes attrition of repeated DNA sequences …