Environmental exposures and autoimmune diseases: contribution of gut microbiome

MF Khan, H Wang - Frontiers in immunology, 2020 - frontiersin.org
Environmental agents have been gaining more attention in recent years for their role in the
pathogenesis of autoimmune diseases (ADs). Increasing evidence has linked environmental …

[PDF][PDF] Immunological effects of silica and asbestos

T Otsuki, M Maeda, S Murakami, H Hayashi… - Cell Mol …, 2007 - researchgate.net
Silicosis patients (SILs) develop respiratory fibrosis and impaired their pulmonary function.
In addition, silica is known as one of the strongest environmental substances causing …

An autoimmunogenic and proinflammatory profile defined by the gut microbiota of patients with untreated systemic lupus erythematosus

B Chen, X Jia, J Xu, L Zhao, J Ji, B Wu… - Arthritis & …, 2021 - Wiley Online Library
Objective Changes in gut microbiota have been linked to systemic lupus erythematosus
(SLE), but knowledge is limited. Our study aimed to provide an in‐depth understanding of …

Silicosis and autoimmunity

S Lee, H Hayashi, H Mastuzaki… - Current opinion in …, 2017 - journals.lww.com
Silicosis and autoimmunity : Current Opinion in Allergy and Clinical Immunology Silicosis and
autoimmunity : Current Opinion in Allergy and Clinical Immunology Log in or Register Subscribe …

Silica-directed mast cell activation is enhanced by scavenger receptors

JM Brown, EJ Swindle, NM Kushnir-Sukhov… - American journal of …, 2007 - atsjournals.org
Inhalation of crystalline silica results in pulmonary fibrosis and silicosis. It has been
suggested that mast cells play a role in these conditions. How mast cells would influence …

Dysregulation of the immune system caused by silica and asbestos

M Maeda, Y Nishimura, N Kumagai… - Journal of …, 2010 - Taylor & Francis
Silica and asbestos cause pneumoconioses known as silicosis and asbestosis, respectively,
that are each characterized by progressive pulmonary fibrosis. While local effects of inhaled …

Environmental factors producing autoimmune dysregulation–chronic activation of T cells caused by silica exposure

S Lee, H Hayashi, M Maeda, Y Chen, H Matsuzaki… - Immunobiology, 2012 - Elsevier
Autoimmune disorders are induced by various environmental and occupational substances.
Among the most typical factors involving these substances, it is well known that silica …

Silica exposure and altered regulation of autoimmunity

S Lee, H Matsuzaki, N Kumagai-Takei… - … health and preventive …, 2014 - Springer
Silica particles and asbestos fibers, which are known as typical causatives of
pneumoconiosis, induce lung fibrosis. Moreover, silicosis patients often complicate with …

Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells

Y Miura, Y Nishimura, H Katsuyama, M Maeda… - Apoptosis, 2006 - Springer
To analyze the possibility that immunological alteration in asbestos-related diseases (ARDs)
such as asbestosis (ASB) and malignant mesothelioma (MM) may affect the progression of …

Alterations of Fas and Fas-related molecules in patients with silicosis

T Otsuki, Y Miura, Y Nishimura… - Experimental …, 2006 - journals.sagepub.com
Persons with silicosis have not only respiratory disorders but also autoimmune diseases. To
clarify the mechanisms involved in the dysregulation of autoimmunity found in patients with …