Background & Aims Noninvasive tests (NITs) of liver fibrosis have been suggested to be less
accurate in type 2 diabetes mellitus (T2DM). We aimed to compare the accuracy of 6 NITs …

Abstract α2-Macroglobulin is a highly abundant serum protein involved in the development
of atherosclerosis and cardiac hypertrophy. However, its circulating molecular form and …

Sickle cell nephropathy (SCN) is a leading cause of morbidity and mortality in sickle cell
disease (SCD). Early intervention is crucial for mitigating its effects. However, current …

Hyperinsulinemia is the key feature of equine metabolic syndrome (EMS) which leads to
debilitating sequelae. Hyperinsulinemia-associated laminitis (HAL) is one of the major …

Abstract Context: Free fatty acids (FFAs) and triglycerides (TGs) are altered postburn, but
whether these alterations are associated with postburn outcomes is not clear. Objective: The …

Aims: Alpha-2-macroglobulin (α2 MG) is thought to be associated with inflammatory
reactions and procoagulant properties that might cause ischemic stroke. Endothelial …

Alpha2-macroglobulin is a protease inhibitor that enhances procoagulant properties via the
neutralization of plasmin, plasminogen activators and metalloproteinases. Additionally …

OBJECTIVE: Despite the number of potential biomarker proteins for diabetes, very few of
them have proven useful as clinically beneficial indicators, because of the technical …

Cardiac isoform of alpha-2 macroglobulin [cardiac α2M] has been shown to be an early
marker in cardiac hypertrophy and left ventricular mass in humans. We, here, for the first time …

Activated alpha-2 Macroglobulin (α2M*) is specifically recognized by the cluster I/II of LRP1
(Low-density lipoprotein Receptor-related Protein-1). LRP1 is a scaffold protein for insulin …