Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Human gut microbiota has been increasingly recognized as a pivotal determinant of non-
alcoholic fatty liver disease (NAFLD). Apart from the changes in the composition of gut …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Objective Acute pancreatitis is caused by toxins that induce acinar cell calcium overload,
zymogen activation, cytokine release and cell death, yet is without specific drug therapy …

Recent advances challenge the long-believed trypsin-centered understanding of
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …

Key points This work confirms previous reports that CM4620, a small molecule inhibitor of
Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction …

Background Pancreatitis in cats, although commonly diagnosed, still presents many
diagnostic and management challenges. Objective To summarize the current literature as it …

Intracellular Ca2+ signalling is a major signal transductional pathway in non-excitable cells,
responsible for the regulation of a variety of physiological functions. In the secretory …