The discovery of the carcinoembryonic antigen (CEA) as a tumor marker for colorectal
cancer some 50 years ago became the first step in the identification of a much larger family …

ABSTRACT CEACAM1 is an extensively studied cell surface molecule with established
functions in multiple cancer types, as well as in various compartments of the immune system …

Background Aim of this study was to assess the biological function in tumor progression and
metastatic process carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 1 …

Chronic inflammation with progressive age, called inflammaging, contributes to the
pathogenesis of cardiovascular diseases. Previously, we have shown increased vascular …

Rationale: Blood–brain–barrier (BBB) breakdown and cerebral edema result from
postischemic inflammation and contribute to mortality and morbidity after ischemic stroke. A …

Abstract Tissue Inhibitor of Metalloproteinase 2 (TIMP-2) plays an essential role in regulating
matrix remodeling, cell growth, differentiation, angiogenesis and apoptosis in vitro and in …

Carcinoembryonic antigen (CEA, CD66e, CEACAM-5) is a cell-surface–bound glycoprotein
overexpressed and released by many solid tumors that has an autocrine function in cancer …

Cancer cells rely on extensive support from the stroma in order to survive, proliferate and
invade. The tumor stroma is thus an important potential target for anti-cancer therapy …

Brain metastases (BM) are the most common brain tumors of adults and are associated with
fatal prognosis. Formation of new blood vessels, named angiogenesis, was proposed to be …

Breast cancer (BC) is the most common cancer occurring in women but also rarely develops
in men. Recent advances in early diagnosis and development of targeted therapies have …