Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

AMPA-type glutamate receptors (AMPARs) are responsible for a variety of processes in the
mammalian brain including fast excitatory neurotransmission, postsynaptic plasticity, or …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …

Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …

Even in healthy individuals there is an inexorable agerelated decline in cognitive function.
This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular …

Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …

Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …

To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …