Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

The prime objective for every life form is to deliver its genetic material, intact and unchanged,
to the next generation. This must be achieved despite constant assaults by endogenous and …

Telomeres are specialized nucleoprotein structures, which protect chromosome ends and
have been implicated in the ageing process. Telomere shortening has been shown to …

Cells continually experience stress and damage from exogenous and endogenous sources,
and their responses range from complete recovery to cell death. Proliferating cells can …

The accumulation of senescent disc cells in degenerative intervertebral disc (IVD) suggests
the detrimental roles of cell senescence in the pathogenesis of intervertebral disc …

Cells from organisms with renewable tissues can permanently withdraw from the cell cycle
in response to diverse stress, including dysfunctional telomeres, DNA damage, strong …

Cellular senescence is associated with ageing and cancer in vivo and has a proven tumour-
suppressive function. Common to both ageing and cancer is the generation of DNA damage …

While global chromatin conformation studies are emerging, very little is known about the
chromatin conformation of human telomeres. Most studies have focused on the role of …

The 3′‐ends of human chromosomal DNA terminate in short single‐stranded guanine‐rich
tandem‐repeat sequences. In cancer cells, these are associated with the telomere …

Nucleic acid sequences containing several short runs of guanine nucleotides can form
complex higher order structures, termed quadruplexes. Their occurrence has been most …