[HTML][HTML] Pretomanid resistance: an update on emergence, mechanisms and relevance for clinical practice
Abstract Pretomanid (PA-824), a novel anti-tuberculosis nitroimidazoxazine, has been
approved for multidrug-resistant tuberculosis treatment for a few years. Pretomanid has …
approved for multidrug-resistant tuberculosis treatment for a few years. Pretomanid has …
Advancing the chemotherapy of tuberculous meningitis: a consensus view
S Wasserman, J Donovan, E Kestelyn… - The Lancet Infectious …, 2025 - thelancet.com
Tuberculous meningitis causes death or disability in approximately 50% of affected
individuals and kills approximately 78 200 adults every year. Antimicrobial treatment is …
individuals and kills approximately 78 200 adults every year. Antimicrobial treatment is …
Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs
Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous
meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and …
meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and …
Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis
Background: Cellular metabolism is critical for the host immune function against pathogens,
and metabolomic analysis may help understand the characteristic immunopathology of …
and metabolomic analysis may help understand the characteristic immunopathology of …
[PDF][PDF] Tuberculous Meningitis-New Approaches Needed
S Wasserman, TS Harrison - N Engl J Med, 2023 - openaccess.sgul.ac.uk
The clinical effects of infectious diseases are determined by a complex interplay between
pathogen and immune response, a dynamic ex emplified by tuberculous meningitis. Despite …
pathogen and immune response, a dynamic ex emplified by tuberculous meningitis. Despite …
Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis
Tuberculous meningitis (TB meningitis) is the most devastating form of tuberculosis (TB) and
there is a critical need to optimize treatment. Linezolid is approved for multidrug resistant TB …
there is a critical need to optimize treatment. Linezolid is approved for multidrug resistant TB …
Nano-imaging agents for brain diseases: Environmentally responsive imaging and therapy
F Liang, Q You, X Ma, H Wang, C Wang, Z He, Y Yang… - Nano Research, 2023 - Springer
Precise imaging is essential for the accurate diagnosis and surgical guidance of brain
diseases but it is challenging due to the difficulties in crossing the blood-brain barrier (BBB) …
diseases but it is challenging due to the difficulties in crossing the blood-brain barrier (BBB) …
New approaches for imaging bacteria
SK Jain - Seminars in nuclear medicine, 2023 - Elsevier
Bacterial infections are a major threat to human health. Rapid and accurate diagnosis of
bacterial infections is essential for early interventions and rational use of antibiotic …
bacterial infections is essential for early interventions and rational use of antibiotic …
The Promise of Molecular Imaging: Focus on Central Nervous System Infections
Central nervous system (CNS) infections can lead to high mortality and severe morbidity.
Diagnosis, monitoring, and assessing response to therapy of CNS infections is particularly …
Diagnosis, monitoring, and assessing response to therapy of CNS infections is particularly …
Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
Abstract Background and Objective The use of bedaquiline as a treatment option for drug-
resistant tuberculosis meningitis (TBM) is of interest to address the increased prevalence of …
resistant tuberculosis meningitis (TBM) is of interest to address the increased prevalence of …