RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
A guide to computational methods for G-quadruplex prediction
E Puig Lombardi, A Londoño-Vallejo - Nucleic acids research, 2020 - academic.oup.com
Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …
quadruplexes (G4). Recent methodological developments have allowed the characterization …
Whole genome experimental maps of DNA G-quadruplexes in multiple species
G Marsico, VS Chambers, AB Sahakyan… - Nucleic acids …, 2019 - academic.oup.com
Genomic maps of DNA G-quadruplexes (G4s) can help elucidate the roles that these
secondary structures play in various organisms. Herein, we employ an improved version of a …
secondary structures play in various organisms. Herein, we employ an improved version of a …
G-quadruplex DNA: a novel target for drug design
FY Teng, ZZ Jiang, M Guo, XZ Tan, F Chen… - Cellular and Molecular …, 2021 - Springer
Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
G-quadruplexes and their ligands: Biophysical methods to unravel G-quadruplex/ligand interactions
Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …
approaches that assess the binding mode and nature of the interactions between G4 …
G4Hunter web application: a web server for G-quadruplex prediction
Motivation Expanding research highlights the importance of guanine quadruplex structures.
Therefore, easy-accessible tools for quadruplex analyses in DNA and RNA molecules are …
Therefore, easy-accessible tools for quadruplex analyses in DNA and RNA molecules are …
Non-B DNA: a major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome
Approximately 13% of the human genome can fold into non-canonical (non-B) DNA
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …
LINE-1 regulates cortical development by acting as long non-coding RNAs
Abstract Long Interspersed Nuclear Elements-1s (L1s) are transposable elements that
constitute most of the genome's transcriptional output yet have still largely unknown …
constitute most of the genome's transcriptional output yet have still largely unknown …
In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
Abstract G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by
guanine-rich sequence folding, and G4 has been computationally predicted to exist in a …
guanine-rich sequence folding, and G4 has been computationally predicted to exist in a …
Design and prediction of aptamers assisted by in silico methods
SJ Lee, J Cho, BH Lee, D Hwang, JW Park - Biomedicines, 2023 - mdpi.com
An aptamer is a single-stranded DNA or RNA that binds to a specific target with high binding
affinity. Aptamers are developed through the process of systematic evolution of ligands by …
affinity. Aptamers are developed through the process of systematic evolution of ligands by …