Designer DNA nanostructures for viral inhibition

S Ren, K Fraser, L Kuo, N Chauhan, AT Adrian… - Nature protocols, 2022 - nature.com
Emerging viral diseases can substantially threaten national and global public health. Central
to our ability to successfully tackle these diseases is the need to quickly detect the causative …

[HTML][HTML] Dengue and human health: A global scenario of its occurrence, diagnosis and therapeutics

MJ Sabir, NBS Al-Saud, SM Hassan - Saudi Journal of Biological Sciences, 2021 - Elsevier
Dengue is one of the highest and rapidly spreading vector-borne viral diseases with high
mortality rates. The infection causes acute febrile illness, a major public health concern in …

Supervised screening of Tecovirimat-like compounds as potential inhibitors for the monkeypox virus E8L protein

A Mehmood, S Nawab, G Jia, AC Kaushik… - Journal of …, 2023 - Taylor & Francis
Monkeypox virus (MPXV) is a budding public health threat worldwide, and there lacks a
personalized drug availability to treat MPXV infections. Tecovirimat, an antiviral drug against …

Mutational landscape of Pirin and elucidation of the impact of most detrimental missense variants that accelerate the breast cancer pathways: a computational …

M Suleman, M Tahir ul Qamar, S Saleem… - Frontiers in Molecular …, 2021 - frontiersin.org
Pirin (PIR) protein is highly conserved in both prokaryotic and eukaryotic organisms.
Recently, it has been identified that PIR positively regulates breast cancer cell proliferation …

Targeting the receptor binding domain and heparan sulfate binding for antiviral drug development against SARS-CoV-2 variants

ZS Yang, TS Li, YS Huang, CC Chang, CM Chien - Scientific Reports, 2024 - nature.com
The emergence of SARS-CoV-2 variants diminished the efficacy of current antiviral drugs
and vaccines. Hence, identifying highly conserved sequences and potentially druggable …

Bringing Structural Implications and Deep Learning-Based Drug Identification for KRAS Mutants

A Mehmood, AC Kaushik, Q Wang, CD Li… - Journal of Chemical …, 2021 - ACS Publications
Colorectal cancer is considered one of the leading causes of death that is linked with the
Kirsten Rat Sarcoma (KRAS) harboring codons 13 and 61 mutations. The objective for this …

Neutralizing antibodies to block viral entry and for identification of entry inhibitors

EH Tam, Y Peng, MXY Cheah, C Yan, T Xiao - Antiviral Research, 2024 - Elsevier
Neutralizing antibodies (NAbs) are naturally produced by our immune system to combat viral
infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have …

Computational screening and analysis of lung cancer related non-synonymous single nucleotide polymorphisms on the human kirsten rat sarcoma gene

Q Wang, A Mehmood, H Wang, Q Xu, Y Xiong, DQ Wei - Molecules, 2019 - mdpi.com
The human KRAS (Kirsten rat sarcoma) is an oncogene, involved in the regulation of cell
growth and division. The mutations in the KRAS gene have the potential to cause normal …

Discovering potent inhibitors against the Mpro of the SARS-CoV-2. A medicinal chemistry approach

A Mehmood, S Nawab, Y Wang, AC Kaushik… - Computers in Biology …, 2022 - Elsevier
The global pandemic caused by a single-stranded RNA (ssRNA) virus known as the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still at its peak, with new cases …

Prediction and validation of potent peptides against herpes simplex virus type 1 via immunoinformatic and systems biology approach

A Mehmood, AC Kaushik… - Chemical Biology & Drug …, 2019 - Wiley Online Library
The human herpes simplex virus type 1 (HSV‐1) is an extremely rampant human pathogen,
and its infection could cause life‐long diseases, including the central nervous system …