Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …

Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …

Autophagy maintains cellular homeostasis during low energy states. According to the
current understanding, glucose-depleted cells induce autophagy through AMPK, the primary …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

Autophagy has been associated with oncogenesis with one of its emerging key functions
being its contribution to the metabolism of tumors. Therefore, deciphering the mechanisms of …

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer,
participating both in tumour growth and cancer progression. Cancer cells develop global …

The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet
mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into …

Autophagy is a self‐digestive process that degrades intracellular components, including
damaged organelles, to maintain energy homeostasis and to cope with cellular stress …

Membrane contact sites (MCS) between organelles of eukaryotic cells provide structural
integrity and promote organelle homeostasis by facilitating intracellular signaling, exchange …

Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are
characterized by unlimited proliferation, transformation and migration, and can destroy …