Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Multiple SARS-CoV-2 variants have mutations in the spike receptor binding domain (RBD)
with potential to evade neutralizing antibody. In particular, the Beta and Omicron variants …

Antibody titers against SARS-CoV-2 slowly wane over time. Here, we examined how time
affects antibody potency. To assess the impact of antibody maturation on durable …

Membrane rafts are dynamic, small (10–200 nm) domains enriched with cholesterol and
sphingolipids that compartmentalize cellular processes. Rafts participate in roles essential to …

The acid sphingomyelinase/ceramide system has been shown to be important for cellular
infection with at least some viruses, for instance, rhinovirus or severe acute respiratory …

Emerging and reemerging infectious diseases have a strong negative impact on public
health. However, because many of these pathogens must be handled in biosafety level, 3 or …

Immunological imprinting by ancestral SARS-CoV-2 strains is thought to impede the robust
induction of Omicron-specific humoral responses by Omicron-based booster vaccines. Here …

Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect
cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The …

In contrast to a second dose of the SARS-CoV-2 mRNA vaccine, a third dose elicits potent
neutralizing activity against the Omicron variant. To address the underlying mechanism for …