Natural killer (NK) cells are lymphocytes with a key role in the defense against viral
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …

Aerosolization of immunotherapies poses incredible potential for manipulating the local
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …

Immunological aging is strongly associated with the observable deleterious effects of human
aging. Our understanding of the causes, effects, and therapeutics of aging immune cells has …

Over the past 50 years in the field of immunology, something of a Copernican revolution has
happened. For a long time, immunologists were mainly concerned with what is termed …

Innate immune memory endows innate immune cells with antigen independent heightened
responsiveness to subsequent challenges. The durability of this response can be mediated …

Abstract Phosphoinositide‐3‐kinase/AKT (PI3K/AKT) signaling plays key roles in the
regulation of cellular activity in both health and disease. In immune cells, this PI3K/AKT …

There is a need for improved vaccine adjuvants to augment vaccine efficacy. One way to
address this is by targeting multiple immune cell pathogen recognition receptors (PRRs) …

The long-lasting humoral immunity induced by viral infections or vaccinations depends on
memory B cells with greatly increased affinity to viral antigens, which are evolved from …

The coronavirus disease 2019 (COVID-19) pandemic causes many morbidity and mortality
cases. Despite several developed vaccines and antiviral therapies, some patients …

Alveolar macrophages (AMs) play a critical role during Mycobacterium tuberculosis (Mtb)
infection as the first cells in the lung to encounter bacteria. We previously showed that AMs …