Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Covering: 2010 up to 2016 Deconvoluting the mode of action of natural products and drugs
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …

The antitumor activity of disulfiram (DSF), a traditional US Food and Drug Administration-
approved drug for the treatment of “alcohol-dependence”, is Cu2+-dependent, but the …

Phenotype-based screening has emerged as an alternative route for discovering new
chemical entities toward first-in-class therapeutics. However, clarifying their mode of action …

Bioorthogonal chemistries can be used to tag diverse classes of biomolecules in cells and
other complex environments. With over 20 unique transformations now available, though …

After more than a century, aspirin remains one of the most commonly used drugs in western
medicine. Although mainly used for its anti-thrombotic, anti-pyretic, and analgesic properties …

Salicylates from plant sources have been used for centuries by different cultures to treat a
variety of ailments such as inflammation, fever and pain. A chemical derivative of salicylic …

Rapamycin is widely recognized as an inhibitor of mTOR, and has been approved for
clinical use as an immunosuppressant. Its potencies in anti-cancer, anti-aging, and …

Highlights•Developing inhibitors against undruggable proteins has remained
challenging.•Activity-based protein profiling enables strategies for mapping druggable …

Natural and traditional medicines, being a great source of drugs and drug leads, have
regained wide interests due to the limited success of high-throughput screening of …