Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

The pleiotropic consequences of nuclear factor of kappa light polypeptide gene enhancer in
B‐cells (NF‐κB) pathway activation result from the combinatorial effects of the five subunits …

Z-conformation nucleic acid binding protein 1 (ZBP1), a powerful innate immune sensor, has
been identified as the important signaling initiation factor in innate immune response and …

Factors linking inflammation and cancer are of great interest. We now report that the
chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B …

The orchestrated organization of epigenetic factors that control chromatin dynamism,
including DNA methylation, histone marks, non-coding RNAs (ncRNAs) and chromatin …

A fundamental property of cells of the innate immune system is their ability to elicit a
transcriptional response to a microbial stimulus or danger signal with a high degree of cell …

The shift to a genotype-first approach in genetic diagnostics has revolutionized our
understanding of neurodevelopmental disorders, expanding both their molecular and …

Dozens of histone methyltransferases have been identified and biochemically characterized,
but the pathological roles of their dysfunction in human diseases such as cancer remain …

Ionizing radiations (IR) alter hematopoietic stem cell (HSC) function on the long term, but the
mechanisms underlying these effects are still poorly understood. We recently showed that IR …

In the present study, we aimed to establish and characterize a mature cortical spheroid
model system for Kleefstra syndrome (KS) using patient-derived iPSC. We identified key …