Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Nausea and vomiting are common gastrointestinal complaints that can be triggered by
diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and …

The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in
maintaining cellular calcium balance. This review traces the history of research on store …

Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat
cardiovascular diseases (CVD) in China and other Asia countries. Here, we summarize …

Store-operated calcium entry (SOCE) is a ubiquitous Ca 2+ entry pathway that is activated in
response to depletion of ER-Ca 2+ stores and critically controls the regulation of …

Astrocytes, once believed to serve only as “glue” for the structural support of neurons, have
been demonstrated to serve critical functions for the maintenance and protection of neurons …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …