Prebiotic peptides: Molecular hubs in the origin of life

M Frenkel-Pinter, M Samanta, G Ashkenasy… - Chemical …, 2020 - ACS Publications
The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Multicomponent peptide assemblies

DM Raymond, BL Nilsson - Chemical Society Reviews, 2018 - pubs.rsc.org
Self-assembled peptide nanostructures have been increasingly exploited as functional
materials for applications in biomedicine and energy. The emergent properties of these …

Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering

VP Gray, CD Amelung, IJ Duti, EG Laudermilch… - Acta biomaterialia, 2022 - Elsevier
A core challenge in biomaterials, with both fundamental significance and technological
relevance, concerns the rational design of bioactive microenvironments. Designed properly …

The Bio-SANS instrument at the high flux isotope reactor of Oak Ridge National Laboratory

WT Heller, VS Urban, GW Lynn, KL Weiss… - Journal of Applied …, 2014 - journals.iucr.org
Small-angle neutron scattering (SANS) is a powerful tool for characterizing complex
disordered materials, including biological materials. The Bio-SANS instrument of the High …

Supramolecular aptamer nano-constructs for receptor-mediated targeting and light-triggered release of chemotherapeutics into cancer cells

DK Prusty, V Adam, RM Zadegan, S Irsen… - Nature …, 2018 - nature.com
Platforms for targeted drug-delivery must simultaneously exhibit serum stability, efficient
directed cell internalization, and triggered drug release. Here, using lipid-mediated self …

Molecular simulations of PEGylated biomolecules, liposomes, and nanoparticles for drug delivery applications

H Lee - Pharmaceutics, 2020 - mdpi.com
Since the first polyethylene glycol (PEG) ylated protein was approved by the FDA in 1990,
PEGylation has been successfully applied to develop drug delivery systems through …

Self-assembled 20-nm 64Cu-micelles enhance accumulation in rat glioblastoma

JW Seo, JC Ang, LM Mahakian, S Tam, B Fite… - Journal of Controlled …, 2015 - Elsevier
There is an urgent need to develop nanocarriers for the treatment of glioblastoma multiforme
(GBM). Using co-registered positron emission tomography (PET) and magnetic resonance …

Designed supramolecular filamentous peptides: balance of nanostructure, cytotoxicity and antimicrobial activity

D Xu, L Jiang, A Singh, D Dustin, M Yang… - Chemical …, 2015 - pubs.rsc.org
This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal
balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective …

Stimuli‐Triggered Sol–Gel Transitions of Polypeptides Derived from α‐Amino Acid N‐Carboxyanhydride (NCA) Polymerizations

X He, J Fan, KL Wooley - Chemistry–An Asian Journal, 2016 - Wiley Online Library
The past decade has witnessed significantly increased interest in the development of smart
polypeptide‐based organo‐and hydrogel systems with stimuli responsiveness, especially …

Fabrication of self-assembling nanofibers with optimal cell uptake and therapeutic delivery efficacy

D Xu, DSK Samways, H Dong - Bioactive materials, 2017 - Elsevier
Effective strategies to fabricate finite organic nanoparticles and understanding their structure-
dependent cell interaction is highly important for the development of long circulating …