It is becoming clearer how neurobiological mechanisms generate 'liking'and
'wanting'components of food reward. Mesocorticolimbic mechanisms that enhance …

The central nervous system (CNS) receives information from afferent neurons, circulating
hormones, and absorbed nutrients and integrates this information to orchestrate the actions …

Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

The central nucleus of the amygdala (CEA) is a brain region that integrates external and
internal sensory information and executes innate and adaptive behaviors through distinct …

Daytime napping is a common, heritable behavior, but its genetic basis and causal
relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide …

Calorie-rich diets induce hyperphagia and promote obesity, although the underlying
mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of …

Naturalistic escape requires versatile context-specific flight with rapid evaluation of local
geometry to identify and use efficient escape routes. It is unknown how spatial navigation …

Early-life trauma (ELT) is a risk factor for binge eating and obesity later in life, yet the neural
circuits that underlie this association have not been addressed. Here, we show in mice that …

Considerable recent advancements in elucidating the genetic architecture of sleep traits and
sleep disorders may provide insight into the relationship between sleep and obesity. Despite …

The circuit mechanisms underlying fear-induced suppression of feeding are poorly
understood. To help fill this gap, mice were fear conditioned, and the resulting changes in …