Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …

First cases that point at a correlation between SARS-CoV-2 infections and the development
of Parkinson's disease (PD) have been reported. Currently, it is unclear if there is also a …

Biomolecular condensates present in cells can fundamentally affect the aggregation of
amyloidogenic proteins and play a role in the regulation of this process. While liquid-liquid …

Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …

Alpha-synuclein is an intrinsically disordered, highly dynamic protein that pathogenically
aggregates into inclusion structures called Lewy bodies, in several neurogenerative …

Alpha synuclein (αS) is a~ 14 kDa intrinsically disordered protein. Decades of research have
increased our knowledge on αS yet its physiological function remains largely elusive. The …

The pathological aggregation of α-synuclein (αS) into amyloid fibrils is the hallmark of
Parkinson's disease (PD). The self-assembly and membrane interactions of αS are mainly …

Alpha-synuclein (αSyn) is a highly expressed and conserved protein, typically found in the
presynaptic terminals of neurons. The misfolding and aggregation of αSyn into amyloid …

Intrinsically disordered proteins and regions typically lack a well-defined structure and thus
fall outside the scope of the classic sequence–structure–function relationship. Hence …