The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the
architectural scaffold of multicellular organisms. In addition to its structural role, the ECM …

Cells respond to diverse types of mechanical stimuli using a wide range of plasma
membrane-associated mechanosensitive receptors to convert extracellular mechanical cues …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

This Viewpoint, which accompanies a Special Issue focusing on membrane
mechanosensors, discusses unifying and unique features of both established and emerging …

Abstract Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion
molecules involved in numerous physiological functions. aGPCRs have large multi-domain …

Apicomplexan parasites possess secretory organelles called rhoptries that undergo
regulated exocytosis upon contact with the host. This process is essential for the parasitic …

Three-finger proteins (TFPs), or Ly6/uPAR proteins, are characterized by the beta-structural
LU domain containing three protruding “fingers” and stabilized by four conserved disulfide …

A large portion of the human GPCRome is still in the dark and understudied, consisting even
of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion …

Adhesion G protein‐coupled receptors (aGPCRs) constitute the second largest subclass of
the GPCR superfamily. Although canonical GPCRs are explored pharmacologically as drug …

The mammalian epididymis is the organ for functional sperm maturation. In rodents, the
initial segment, the most proximal region of the epididymis, plays a critical role in sperm …