Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity
Despite their widespread impact on human health, there are no approved drugs for
combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 …
combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 …
High-Throughput SFC-MS/MS Method to Measure EPSA and Predict Human Permeability
YT Wang, E Price, M Feng, J Hulen… - Journal of Medicinal …, 2024 - ACS Publications
Permeability is a key factor driving the absorption of orally administered drugs. In early
discovery, the efficient evaluation of permeability, particularly for compounds violating …
discovery, the efficient evaluation of permeability, particularly for compounds violating …
Exploring the Potential of Adaptive, Local Machine Learning in Comparison to the Prediction Performance of Global Models: A Case Study from Bayer's Caco-2 …
Machine learning (ML) techniques are being widely implemented to fill the gap in simple
molecular design guidelines for newer therapeutic modalities in the extended and beyond …
molecular design guidelines for newer therapeutic modalities in the extended and beyond …
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity
Despite their widespread impact on human health there are no approved drugs for
combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 …
combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 …