Recent advancements in nucleic acid detection with microfluidic chip for molecular diagnostics

Z Li, X Xu, D Wang, X Jiang - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) has extensively promoted the
application of nucleic acid testing technology in the field of clinical testing. The most widely …

Advances in magnetic nanoparticles for the separation of foodborne pathogens: Recognition, separation strategy, and application

F Xiao, W Li, H Xu - … Reviews in Food Science and Food Safety, 2022 - Wiley Online Library
Foodborne pathogens contamination is one of the main sources of food safety problems.
Although the existing detection methods have been developed for a long time, the …

Fully Integrated Microfluidic Biosensor with Finger Actuation for the Ultrasensitive Detection of Escherichia coli O157:H7

Y Shang, G Xing, X Liu, H Lin, JM Lin - Analytical Chemistry, 2022 - ACS Publications
A portable microfluidic biosensor was developed for the detection of E. coli O157: H7 using
finger actuation. The chip was assembled with three functional zones, immunomagnetic …

Magnetic graphene oxide: synthesis approaches, physicochemical characteristics, and biomedical applications

Y He, C Yi, X Zhang, W Zhao, D Yu - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Magnetic graphene oxide, a compound of magnetic nanoparticles and graphene oxide,
possesses distinct physical and chemical characteristics, including nano size, a large …

Rapid on-site nucleic acid testing: On-chip sample preparation, amplification, and detection, and their integration into all-in-one systems

J Wang, H Jiang, L Pan, X Gu, C Xiao, P Liu… - … in Bioengineering and …, 2023 - frontiersin.org
As nucleic acid testing is playing a vital role in increasingly many research fields, the need
for rapid on-site testing methods is also increasing. The test procedure often consists of …

Interfacial Polymerization Produced Magnetic Particles with Nano‐Filopodia for Highly Accurate Liquid Biopsy in the PSA Gray Zone

Y Zhang, F Zhang, Y Song, X Shen, F Bu… - Advanced …, 2023 - Wiley Online Library
Magnetic particles are leading separation materials for biological purification and detection.
Existing magnetic particles, which almost rely on molecule‐level interactions, however, often …

Magnetic Nanocomposites and Imprinted Polymers for Biomedical Applications of Nucleic Acids

V Popova, E Dmitrienko, A Chubarov - Magnetochemistry, 2022 - mdpi.com
Magnetic nanocomposites (MNCs) combine the features of magnetic nanoparticles and a
second material, which provide distinct physical, chemical, and biological properties. The …

Microfluidics: the propellant of CRISPR-based nucleic acid detection

Y Chen, S Qian, X Yu, J Wu, J Xu - Trends in Biotechnology, 2023 - cell.com
Since the discovery of collateral cleavage activity, clustered regularly interspaced short
palindromic repeats (CRISPR)/Cas systems have become the new generation of nucleic …

Multiple crRNAs-assisted CRISPR/Cas12a assay targeting cytochrome b gene for amplification-free detection of meat adulteration

Y Chen, T Yang, S Qian, C Peng, X Wang, T Wang… - Analytica Chimica …, 2022 - Elsevier
Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas systems have
been widely applied in nucleic acid analysis for the high specificity. Coupled with pre …

Bridging the gap between development of point-of-care nucleic acid testing and patient care for sexually transmitted infections

K Hsieh, JH Melendez, CA Gaydos, TH Wang - Lab on a Chip, 2022 - pubs.rsc.org
The incidence rates of sexually transmitted infections (STIs), including the four major curable
STIs–chlamydia, gonorrhea, trichomoniasis and, syphilis–continue to increase globally …