Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the
tumor by interfering with specific molecular targets and are currently the focus of anticancer …

Cell signaling via inositol phosphates, in particular via the second messenger myo‐inositol
1, 4, 5‐trisphosphate, and phosphoinositides comprises a huge field of biology. Of the nine …

Akt/PKB is a key master regulator of a wide range of physiological functions including
metabolism, proliferation, survival, growth, angiogenesis and migration and invasion. The …

The signalling system known as mammalian target of rapamycin (mTOR) is believed to be
required for several biological activities involving cell proliferation. The serine-threonine …

Although the prognosis of patients with localized prostate cancer is good after surgery, with
a favorable response to androgen deprivation therapy, about one third of them invariably …

The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …

The PI3-kinase (PI3K) pathway regulates many cellular processes, especially cell
metabolism, cell survival, and apoptosis. Phosphatidylinositol-3, 4, 5-trisphosphate (PIP3) …

The phosphoinositide 3-kinase (PI3K) signaling pathway controls a wide variety of cellular
processes including cell death and survival, cell migration, protein synthesis and …

The accumulation of metabolites in the intervertebral disc is considered an important cause
of intervertebral disc degeneration (IVDD). Lactic acid, which is a metabolite that is produced …