Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …

FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of
magnitude higher than what is currently used in conventional clinical radiotherapy, and has …

Importance To our knowledge, there have been no clinical trials of ultra-high-dose-rate
radiotherapy delivered at more than 40 Gy/sec, known as FLASH therapy, nor first-in-human …

Purpose: Recent data have shown that single-fraction irradiation delivered to the whole
brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit …

Abstract FLASH radiotherapy (FLASH-RT) is a technology that could modify the way
radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of …

Purpose Recent studies suggest that ultrahigh-dose-rate,“FLASH,” electron radiation
therapy (RT) decreases normal tissue damage while maintaining tumor response compared …

Background When compared to conventional radiotherapy (RT) in pre-clinical studies,
FLASH-RT was shown to reproducibly spare normal tissues, while preserving the anti-tumor …

Purpose: Previous studies using FLASH radiotherapy (RT) in mice showed a marked
increase of the differential effect between normal tissue and tumors. To stimulate clinical …

Here, we highlight the potential translational benefits of delivering FLASH radiotherapy
using ultra-high dose rates (> 100 Gy⋅ s− 1). Compared with conventional dose-rate …

Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …