Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Persistent pain, which is poorly treated and estimated to afflict one third of the world's
population, is largely mediated by the sensitization of nociceptive neurons. This sensitization …

Dysfunction in regulation of mRNA translation is an increasingly recognized characteristic of
many diseases and disorders, including cancer, diabetes, autoimmunity …

Pain is a major non-motor symptom that contributes to impaired quality of life in Parkinson's
disease (PD). However, the mechanisms and treatment of pain in PD have not been well …

Background Glial activation and neuroinflammation in the spinal trigeminal nucleus (STN)
play a pivotal role in the genesis and maintenance of trigeminal neuralgia (TN). Resveratrol …

Background Irritable bowel syndrome (IBS) is a common functional disease characterized by
chronic abdominal pain and changes in bowel movements. Effective therapy for visceral …

Paclitaxel is a chemotherapeutic agent widely used for treating carcinomas. Patients
receiving paclitaxel often develop neuropathic pain and have a reduced quality of life which …

Chronic pain is a major clinical problem that is poorly treated with available therapeutics.
Adenosine monophosphate-activated protein kinase (AMPK) has recently emerged as a …

AMP‐activated protein kinase (AMPK) is an important energy sensor located in cells
throughout the human body. From the periphery, AMPK is known to be a metabolic master …

Neuropathic pain (NP) is a frustrating and burdensome problem. Current treatments for NP
have unendurable side effects and/or questionable efficacy, and once these therapies are …