Neurotoxicology of nanomaterials

WK Boyes, C van Thriel - Chemical research in toxicology, 2020 - ACS Publications
The remarkable advances coming about through nanotechnology promise to revolutionize
many aspects of modern life; however, these advances come with a responsibility for due …

Physiological and pathological factors affecting drug delivery to the brain by nanoparticles

Y Islam, AG Leach, J Smith, S Pluchino… - Advanced …, 2021 - Wiley Online Library
The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is
known to be increasing due to an aging population and is anticipated to further grow in the …

Microglia-targeting nanotherapeutics for neurodegenerative diseases

N Zhao, NL Francis, HR Calvelli, PV Moghe - APL bioengineering, 2020 - pubs.aip.org
Advances in nanotechnology have enabled the design of nanotherapeutic platforms that
could address the challenges of targeted delivery of active therapeutic agents to the central …

Neurotoxicity of metal‐containing nanoparticles and implications in glial cells

X Chang, J Li, S Niu, Y Xue… - Journal of Applied …, 2021 - Wiley Online Library
With the development of nanotechnology, metal‐containing nanoparticles are used widely in
the diagnosis, monitoring and treatment of central nervous system (CNS) diseases. The …

Polymer nanotherapeutics: A promising approach toward microglial inhibition in neurodegenerative diseases

S Keshavarz Shahbaz, K Koushki… - Medicinal Research …, 2024 - Wiley Online Library
Nanoparticles (NPs) that target multiple transport mechanisms facilitate targeted delivery of
active therapeutic agents to the central nervous system (CNS) and improve therapeutic …

Nervous system exposure of different classes of nanoparticles: A review on potential toxicity and mechanistic studies

M Gao, Z Yang, Z Zhang, L Chen, B Xu - Environmental Research, 2024 - Elsevier
Nanoparticles (NPs) are generally defined as very small particles in the size range of 1-100
nm. Due to the rapid development of modern society, many new materials have been …

Silver nanoparticle-induced impaired autophagic flux and lysosomal dysfunction contribute to the microglia inflammation polarization

M Shang, S Niu, X Chang, J Li, W Zhang, M Guo… - Food and Chemical …, 2022 - Elsevier
Silver nanoparticles (AgNPs) have been incorporated in many consumer and biomedical
products. Serious concerns have been expressed about the environmental and public …

Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review

C Jalili, A Kiani, M Gholami… - IET …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the chief neurological difficulties in the aged population,
identified through dementia, memory disturbance, and reduced cognitive abilities. β‐amyloid …

Intranasal administration of gold nanoparticles designed to target the central nervous system: fabrication and comparison between nanospheres and nanoprisms

E Gallardo-Toledo, A Tapia-Arellano, F Celis… - International Journal of …, 2020 - Elsevier
The presence of the blood–brain barrier (BBB) limit gold nanoparticles (GNP) accumulation
in central nervous system (CNS) after intravenous (IV) administration. The intranasal (IN) …

The key role of autophagy in silver nanoparticle-induced BV2 cells inflammation and polarization

M Shang, X Chang, S Niu, J Li, W Zhang, T Wu… - Food and Chemical …, 2021 - Elsevier
As the release of silver nanoparticles (AgNPs) in the environment continues to increase,
great concerns have been raised about their potential toxicity to humans. It is urgent to …