Cardiovascular (CV) diseases and cancer are the leading causes of death in Europe and
the United States. Both diseases have extensive overlap and share common risk factors …

Abstract Introduction Natural products (NPs) play a crucial role in the development of
therapeutic drugs. However, it is still highly challenging to identify the targets of NPs …

Nitrogen mustards (NM) are an important class of chemotherapeutic drugs used in the
treatment of malignant tumors. The accepted mechanism of action of NM is through the …

Over 80% of triple negative breast cancers express mutant p53. Mutant p53 often gains
oncogenic function suggesting that triple negative breast cancers may be driven by p53 …

Bladder cancer is mostly present in the form of urothelium carcinoma, causing over 150,000
deaths each year. Its histopathological classification as muscle invasive (MIBC) and non …

Human REXO4 is a poorly characterized exonuclease that is overexpressed in human
cancers. To better understand the function of REXO4 and its relationship to cellular …

Treating breast carcinoma gets tedious due to its invasive molecular subtypes and their
various molecular genotypes. Depending upon genotype and phenotype of breast tumor …

DNA, a crucial biomolecule, can undergo damage from both exogenous and endogenous
sources. Examples of common DNA damage products include abasic sites (AP sites) …

We recently found and studied a new class of antimicrotubule agents named phenyl 4-(2-
oxo-3-alkylimidazolidin-1-yl) benzenesulfonates (PAIB-SOs) that are highly active and …

Abasic (AP) sites are the most common type of lesions in DNA. Numerous endogenous and
exogenous agents and cellular processes can induce the formation of AP sites in DNA. If left …