Ex-vivo machine perfusion represents a superior organ preservation method over static cold
storage. There is still an urgent need for the optimization of the perfusion fluid and machine …

A great deal of research is still needed to optimize and logistically place hypothermic and
normothermic perfusion technologies. In the future, we may progress toward organ-tailored …

Background Supplemental oxygenation of the standard hypothermic machine perfusion
(HMP) circuit has the potential to invoke favorable changes in metabolism, optimizing …

In solid organ transplantation (Tx), both survival rates and quality of life have improved
dramatically over the last few decades. Each year, the number of people on the wait list …

Isotope labeling enables the use of 13 C-based metabolomics techniques with strongly
improved resolution for a better identification of relevant metabolites and tracing of metabolic …

Hypothermic machine perfusion (HMP) and static cold storage (SCS) are the two methods
used to preserve deceased donor kidneys prior to transplant. This study seeks to …

Intrinsically disordered proteins (IDPs) constitute an important class of biomolecules with
high flexibility. Atomic-resolution studies for these molecules are essentially limited to NMR …

This is a broad overview and critical review of a particular group of closely related ex vivo
and in vitro metabolic NMR spectroscopic methods. The scope of interest comprises studies …

Most kidney grafts are marginal and from deceased donors, which yield worse clinical
outcomes. Hypothermic machine perfusion has created a paradigm shift in kidney …

Background Understanding kidney metabolism during perfusion is vital to further develop
the technology as a preservation, viability assessment, and resuscitation platform. We …