Proteins constitute a key class of molecular components that perform essential biochemical
reactions in living cells. Whether the aim is to extensively characterize a given protein or to …

Milk is a complex body fluid aimed at addressing the nutritional and defensive needs of the
mammal's newborns. Harbored microbiota plays a pivotal role throughout the cheesemaking …

De novo peptide sequencing, which does not rely on a comprehensive target sequence
database, provides us with a way to identify novel peptides from tandem mass spectra …

Compared to other data‐intensive disciplines such as genomics, public deposition and
storage of MS‐based proteomics, data are still less developed due to, among other reasons …

Sequence database search engines are bioinformatics algorithms that identify peptides from
tandem mass spectra using a reference protein sequence database. Two decades of …

The availability of extensive genome information for many different microbes, including
unculturable species in mixed communities from environmental samples, has enabled …

While peptide identifications in mass spectrometry (MS)-based shotgun proteomics are
mostly obtained using database search methods, high-resolution spectrum data from …

The complexities of tumor genomes are rapidly being uncovered, but how they are regulated
into functional proteomes remains poorly understood. Standard proteomics workflows use …

Abstract1 Short open reading frame (sORF)–encoded polypeptides (SEPs) have recently
emerged as key regulators of major cellular processes. Computational methods for the …

Diabetes, a glucose metabolic disorder, is considered one of the biggest challenges
associated with a complex complication of health crises in the modern lifestyle. Inhibition or …