Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits

MC de Hemptinne, D Posthuma - Nature neuroscience, 2023 - nature.com
Genome-wide association studies have led to the identification of robust statistical
associations of genetic variants with numerous brain-related traits, including neurological …

[HTML][HTML] Genetic counseling and testing for Asian Americans: a systematic review

JL Young, J Mak, T Stanley, M Bass, MK Cho… - Genetics in …, 2021 - Elsevier
Abstract Purpose Asian Americans have been understudied in the literature on genetic and
genomic services. The current study systematically identified, evaluated, and summarized …

Essentially biased: Why people are fatalistic about genes

SJ Heine, I Dar-Nimrod, BY Cheung, T Proulx - Advances in experimental …, 2017 - Elsevier
We propose that people are genetic essentialists—that is, they tend to think of genetic
attributions as being immutable, of a specific etiology, natural, and dividing people into …

Polygenic risk scoring of human embryos: a qualitative study of media coverage

T Pagnaer, M Siermann, P Borry, O Tšuiko - BMC Medical Ethics, 2021 - Springer
Background Current preimplantation genetic testing (PGT) technologies enable embryo
genotyping across the whole genome. This has led to the development of polygenic risk …

What do people think about genetics? A systematic review

E LePoire, B Basu, L Walker, DJ Bowen - Journal of Community Genetics, 2019 - Springer
Genetics is increasingly becoming a part of modern medical practice. How people think
about genetics' use in medicine and their daily lives is therefore essential. Earlier studies …

Public attitudes toward genetic risk scoring in medicine and beyond

S Zhang, RA Johnson, J Novembre, E Freeland… - Social Science & …, 2021 - Elsevier
Advances in genomics research have led to the development of polygenic risk scores, which
numerically summarize genetic predispositions for a wide array of human outcomes. Initially …

Cumulative outcome of pre‐implantation genetic diagnosis for sickle cell disease: a 5‐year review

S Vali, S Mukhtar, A Nandi, K Wilson… - British journal of …, 2020 - Wiley Online Library
To review the cumulative outcome of pre‐implantation genetic diagnosis (PGD) cycles
performed for prevention of sickle cell disease (SCD). Couples referred for PGD for SCD …

A closer look at expanded carrier screening from a PGD perspective

C Vaz-de-Macedo, J Harper - Human Reproduction, 2017 - academic.oup.com
Conventionally, the search for carrier status was based on ethnicity and/or family history and
targeted to a restricted number of genetic conditions and mutations. This is now being …

The decision-making process, experience, and perceptions of preimplantation genetic testing (PGT) users

S Zuckerman, S Gooldin, DA Zeevi… - Journal of Assisted …, 2020 - Springer
Purpose The decision to undergo preimplantation genetic testing (PGT) entails a variety of
personal and societal variables. Although PGT technology is widely accepted and used, few …

Offering preimplantation genetic testing for monogenic disorders (PGT‐M) for conditions with reduced penetrance or variants of uncertain significance: Ethical insight …

A Porto, R Gaber Caffrey… - Journal of genetic …, 2022 - Wiley Online Library
Preimplantation genetic testing for monogenic disorders (PGT‐M) was originally developed
to identify embryos affected with serious childhood‐onset disorders, but its use has recently …