From pre-diabetes to diabetes: diagnosis, treatments and translational research

RMM Khan, ZJY Chua, JC Tan, Y Yang, Z Liao, Y Zhao - Medicina, 2019 - mdpi.com
Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time.
According to the 2017 International Diabetes Federation (IDF) statistics, the global …

Role of magnesium in type 2 diabetes mellitus

J Feng, H Wang, Z Jing, Y Wang, Y Cheng… - Biological trace element …, 2020 - Springer
Magnesium (in its ionized and biologically active form, Mg 2+) is an essential trace element
that participates in numerous physiologic processes. Abnormal Mg 2+ homeostasis can lead …

Hypoglycemic effect of a novel polysaccharide from Lentinus edodes on STZ-induced diabetic mice via metabolomics study and Nrf2/HO-1 pathway

P Gong, X Wang, M Liu, M Wang, S Wang, Y Guo… - Food & Function, 2022 - pubs.rsc.org
Objective: With the rising prevalence of diabetes worldwide, increased attention is focused
on natural drug candidates that can treat diabetes with high efficacy but without undesired …

Pharmacogenetics of novel glucose-lowering drugs

W Rathmann, B Bongaerts - Diabetologia, 2021 - Springer
The aim of this work was to review studies in which genetic variants were assessed with
respect to metabolic response to treatment with novel glucose-lowering drugs: dipeptidyl …

A review of type 2 diabetes mellitus predisposing genes

TO Yahaya, TF Salisu - Current diabetes reviews, 2020 - ingentaconnect.com
Introduction: Scientists are considering the possibility of treating diabetes mellitus (DM)
using a personalized approach in which various forms of the diseases will be treated based …

Next generation sequencing targeted gene panel in Greek MODY patients increases diagnostic accuracy

EB Tatsi, C Kanaka‐Gantenbein, A Scorilas… - Pediatric …, 2020 - Wiley Online Library
Abstract Background Maturity Onset Diabetes of the Young (MODY) constitutes a genetically
and clinically heterogeneous type of monogenic diabetes. It is characterized by early onset …

[HTML][HTML] Nutrigenomics of inward rectifier potassium channels

G Ferreira, A Santander, R Cardozo, L Chavarría… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Inwardly rectifying potassium (Kir) channels play a key role in maintaining the resting
membrane potential and supporting potassium homeostasis. There are many variants of Kir …

[HTML][HTML] Pharmacogenetic studies update in type 2 diabetes mellitus

S Singh, K Usman, M Banerjee - World journal of diabetes, 2016 - ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is a silent progressive polygenic metabolic disorder
resulting from ineffective insulin cascading in the body. World-wide, about 415 million …

GNAS gene is an important regulator of insulin secretory capacity in pancreatic β-cells

J Taneera, S Dhaiban, AK Mohammed… - Gene, 2019 - Elsevier
Abstract Background Type 2 diabetes (T2D) is a complex polygenic disease with unclear
mechanism. In an attempt to identify novel genes involved in β-cell function, we harness a …

Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: a case-control study

TD Aka, U Saha, SA Shati, MA Aziz, M Begum… - Heliyon, 2021 - cell.com
Background Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are two
deadly diseases caused by the complex interaction of multiple genetic loci, lifestyle and …