Phytocannabinoids beyond the Cannabis plant – do they exist?

J Gertsch, RG Pertwee… - British journal of …, 2010 - Wiley Online Library
It is intriguing that during human cultural evolution man has detected plant natural products
that appear to target key protein receptors of important physiological systems rather …

Transport of endocannabinoids across the plasma membrane and within the cell

CJ Fowler - The FEBS journal, 2013 - Wiley Online Library
Endocannabinoids are readily accumulated from the extracellular space by cells. Although
their uptake properties have the appearance of a process of facilitated diffusion, it is by no …

Soybeans as a phytochemical reservoir for the production and stabilization of biocompatible gold nanoparticles

R Shukla, SK Nune, N Chanda, K Katti, S Mekapothula… - Small, 2008 - Wiley Online Library
The present study demonstrates an unprecedented green process for the production of gold
nanoparticles by simple treatment of gold salts with soybean extracts. Reduction capabilities …

Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview

F Nazari‐Khanamiri… - Journal of Food …, 2021 - Wiley Online Library
Genistein is the simplest secondary metabolite in soybeans and belongs to a group of
compounds called isoflavones. It is a phytoestrogen and it makes up more than 60% of soy …

Insights into cellular uptake of nanoparticles

M Hasanzadeh Kafshgari, FJ Harding… - Current drug …, 2015 - ingentaconnect.com
Nanomaterials promise to improve disease diagnosis and treatment by enhancing the
delivery of drugs, genes, biomolecules and imaging agents to specific subcellular targets. In …

Mediterranean diet and neurodegenerative diseases: the neglected role of nutrition in the modulation of the endocannabinoid system

F Armeli, A Bonucci, E Maggi, A Pinto, R Businaro - Biomolecules, 2021 - mdpi.com
Neurodegenerative disorders are a widespread cause of morbidity and mortality worldwide,
characterized by neuroinflammation, oxidative stress and neuronal depletion. The broad …

Anandamide uptake explained?

CJ Fowler - Trends in pharmacological sciences, 2012 - cell.com
The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from
the extracellular space by a process of cellular uptake followed by metabolism. Although the …

Delta9‐tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: A critical examination of the preclinical literature

CJ Fowler - Clinical Pharmacology & Therapeutics, 2015 - Wiley Online Library
An Internet search with search words “cannabis cures cancer” produce a wealth of sites
claiming that cannabis has this effect. These sites are freely accessible to the general public …

Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids

L Thors, M Belghiti, CJ Fowler - British journal of pharmacology, 2008 - Wiley Online Library
Background and purpose: Recent studies have demonstrated that the naturally occurring
isoflavone compounds genistein and daidzein inhibit the hydrolysis of anandamide by fatty …

Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase

L Thors, JJ Burston, BJ Alter… - British Journal of …, 2010 - Wiley Online Library
Background and purpose: Inhibitors of fatty acid amide hydrolase (FAAH), the enzyme
responsible for the metabolism of the endogenous cannabinoid (CB) receptor ligand …