The molecular regulation of smooth muscle cell (SMC) behavior is reviewed, with particular
emphasis on stimuli that promote the contractile phenotype. SMCs can shift reversibly along …

Recent studies have shown that extracellular matrix (ECM) substitutes can have a dramatic
impact on cell growth, differentiation and function. However, these ECMs are often applied …

Chronic asthma is an inflammatory airways disease characterized by pathological changes
in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and …

Defining mechanisms by which differentiated, contractile smooth muscle cells become
proliferative and secretory in response to mechanical and environmental stress is crucial for …

Airway smooth muscle (ASM) plays a key role in the development of airway
hyperresponsiveness and remodeling in asthma, which may involve maturation of ASM cells …

The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM
phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the …

Asthma is characterized by the association of airway hyperresponsiveness (AHR),
inflammation, and remodelling. The aim of the present article is to review the pivotal role of …

Airway smooth muscle (ASM) cells exhibit phenotype plasticity that is under control of
external stimuli such as growth factors and the extracellular matrix, and is regulated by a …

Since ancient times, anticholinergics have been used as a bronchodilator therapy for
obstructive lung diseases. Targets of these drugs are G-protein-coupled muscarinic M1, M2 …

Asthma is a frequent respiratory condition whose pathophysiology relies on altered
interactions between bronchial epithelium, smooth muscle cells (SMC) and immune …