When light meets biology–how the specimen affects quantitative microscopy
Fluorescence microscopy images should not be treated as perfect representations of
biology. Many factors within the biospecimen itself can drastically affect quantitative …
biology. Many factors within the biospecimen itself can drastically affect quantitative …
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons
S Bracha, HJ Johnson, NA Pranckevicius, F Catto… - Nature …, 2024 - nature.com
Delivering macromolecules across biological barriers such as the blood–brain barrier limits
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …
[HTML][HTML] NEAT1 is overexpressed in Parkinson's disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress
A Simchovitz, M Hanan, N Niederhoffer… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Recent reports attribute numerous regulatory functions to the nuclear paraspeckle-forming
long noncoding RNA, nuclear enriched assembly transcript 1 (NEAT1), but the implications …
long noncoding RNA, nuclear enriched assembly transcript 1 (NEAT1), but the implications …
It's clearly the heart! Optical transparency, cardiac tissue imaging, and computer modelling
Recent developments in clearing and microscopy enable 3D imaging with cellular resolution
up to the whole organ level. These methods have been used extensively in neurobiology …
up to the whole organ level. These methods have been used extensively in neurobiology …
Multiclass classification of autofluorescence images of oral cavity lesions based on quantitative analysis
Background Oral cancer is one of the most common diseases globally. Conventional oral
examination and histopathological examination are the two main clinical methods for …
examination and histopathological examination are the two main clinical methods for …
High‐throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory‐deprived cortical cholinergic VIP/CHAT neurons
Cortical neuronal networks control cognitive output, but their composition and modulation
remain elusive. Here, we studied the morphological and transcriptional diversity of cortical …
remain elusive. Here, we studied the morphological and transcriptional diversity of cortical …
RNA splicing analysis: from in vitro testing to single-cell imaging
RNA splicing is a fundamental regulatory process of gene expression and plays a pivotal
role in transcriptome complexity, cell-fate determination, and organism development. The …
role in transcriptome complexity, cell-fate determination, and organism development. The …
Young adult-born neurons improve odor coding by mitral cells
New neurons are continuously generated in the adult brain through a process called adult
neurogenesis. This form of plasticity has been correlated with numerous behavioral and …
neurogenesis. This form of plasticity has been correlated with numerous behavioral and …
Cortical VIP+/ChAT+ interneurons: From genetics to function
One of the urgent tasks of neuroscience is to understand how neuronal circuits operate,
what makes them fail, and how to repair them when needed. Achieving this goal requires …
what makes them fail, and how to repair them when needed. Achieving this goal requires …
MicroRNA-210-3p targets RGMA to enhance the angiogenic functions of endothelial progenitor cells under hypoxic conditions
WJ Lu, HB Liang, YF Li, XQ Tu, JR He… - Frontiers in Cellular …, 2019 - frontiersin.org
Endothelial progenitor cells (EPCs) are multipotential stem cells considered to have
immense clinical value for revascularization. However, the clinical application of EPCs has …
immense clinical value for revascularization. However, the clinical application of EPCs has …