The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Obesity is characterized by the excessive deposition of fat that may interfere with the normal
metabolic process of the body. It is a chronic condition associated with various metabolic …

Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease. The natural history of DKD includes glomerular hyperfiltration …

Atherosclerosis, the major cause of myocardial infarction and stroke, results from converging
inflammatory, metabolic, and biomechanical factors. Arterial lesions form at sites of low and …

Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-
associated pathologies. In this review, we discuss physiological functions of KLFs in the …

The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class
switching, and germinal center (GC) formation. The Tfh cells are characterized by the …

The role of inflammation in vascular disease is well recognized, involving dysregulation of
both circulating immune cells as well as the cells of the vessel wall itself. Unrestrained …

Diabetic cardiomyopathy (DCM) is a disorder of the heart muscle in people with diabetes
that can occur independent of hypertension or vascular disease. The underlying mechanism …

KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly
conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and …