Thiophene‐containing compounds with antimicrobial activity
G Roman - Archiv der Pharmazie, 2022 - Wiley Online Library
Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …
Folate pathway inhibitors, an underestimated and underexplored molecular target for new anti-tuberculosis agents
SV Vassiliades, LG Borges, J Giarolla… - Mini Reviews in …, 2023 - ingentaconnect.com
The folate metabolic cycle is an important biochemical process for the maintenance of
cellular homeostasis, and is a widely studied pathway of cellular replication control in all …
cellular homeostasis, and is a widely studied pathway of cellular replication control in all …
Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents
In connection with our research program on the development of novel anti-tubercular
candidates, herein we report the design and synthesis of two different sets of indole …
candidates, herein we report the design and synthesis of two different sets of indole …
Development of Novel Isatin-Tethered Quinolines as Anti-Tubercular Agents against Multi and Extensively Drug-Resistant Mycobacterium tuberculosis
We describe the design and synthesis of two isatin-tethered quinolines series (Q6a–h and
Q8a–h), in connection with our research interest in developing novel isatin-bearing anti …
Q8a–h), in connection with our research interest in developing novel isatin-bearing anti …
First X-ray Crystal Structure Characterization, Computational Studies, and Improved Synthetic Route to the Bioactive 5-Arylimino-1, 3, 4-thiadiazole Derivatives
N-arylcyanothioformamides are useful coupling components for building key chemical
intermediates and biologically active molecules in an expedited and efficient manner …
intermediates and biologically active molecules in an expedited and efficient manner …
Sulfonamide-salicylaldehyde Imines Active Against methicillin- and trimethoprim/sulfonamide-resistant Staphylococci
M Krátký, K Konečná, J Janoušek… - Future Medicinal …, 2021 - Taylor & Francis
Background: Increasing resistance has resulted in an urgent need for new antimicrobial
drugs. A systematic me-too approach was chosen to modify clinically used sulfonamides to …
drugs. A systematic me-too approach was chosen to modify clinically used sulfonamides to …
Current development of 5-nitrofuran-2-yl derivatives as antitubercular agents
Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis
(MTB) and still remains one of the foremost fatal infectious diseases, infecting nearly a third …
(MTB) and still remains one of the foremost fatal infectious diseases, infecting nearly a third …
Synthesis, Antimicrobial, and Anticancer Activities of Novel Nitrofuran Derivatives
Keeping in view the varying therapeutic attributes of 5‐nitrofuran and isatin derivatives,
novel 5‐nitrofuran‒isatin molecular hybrids (2, 5–7) were synthesized by standard …
novel 5‐nitrofuran‒isatin molecular hybrids (2, 5–7) were synthesized by standard …
First Exclusive Stereo‐and Regioselective Preparation of 5‐Arylimino‐1, 3, 4‐Selenadiazole Derivatives: Synthesis, NMR analysis, and Computational Studies
Isoselenocyanates are valuable coupling partners required for preparing key chemical
intermediates and biologically active molecules in an accelerated and effective way …
intermediates and biologically active molecules in an accelerated and effective way …
Synthesis and biological evaluation of 2-aminothiazole-thiazolidinone conjugates as potential antitubercular agents
Aim: Mycobacterium tuberculosis, which causes tuberculosis, continues to infect millions of
the global population, resulting in 1.8 million deaths worldwide in 2015. Methodology …
the global population, resulting in 1.8 million deaths worldwide in 2015. Methodology …