Cancer health disparities in racial/ethnic minorities in the United States
VA Zavala, PM Bracci, JM Carethers… - British journal of …, 2021 - nature.com
There are well-established disparities in cancer incidence and outcomes by race/ethnicity
that result from the interplay between structural, socioeconomic, socio-environmental …
that result from the interplay between structural, socioeconomic, socio-environmental …
Genetic epidemiology of breast cancer in Latin America
The last 10 years witnessed an acceleration of our understanding of what genetic factors
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …
Origins, admixture dynamics, and homogenization of the African gene pool in the Americas
Abstract The Transatlantic Slave Trade transported more than 9 million Africans to the
Americas between the early 16th and the mid-19th centuries. We performed a genome-wide …
Americas between the early 16th and the mid-19th centuries. We performed a genome-wide …
The Brazilian Initiative on Precision Medicine (BIPMed): fostering genomic data-sharing of underrepresented populations
The development of precision medicine strategies requires prior knowledge of the genetic
background of the target population. However, despite the availability of data from admixed …
background of the target population. However, despite the availability of data from admixed …
The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture
Western South America was one of the worldwide cradles of civilization. The well-known
Inca Empire was the tip of the iceberg of an evolutionary process that started 11,000 to …
Inca Empire was the tip of the iceberg of an evolutionary process that started 11,000 to …
[HTML][HTML] Challenges of diagnostic genomics in Latin America
RM Alvarez-Gomez… - Current Opinion in …, 2021 - Elsevier
Cancer genome sequencing methods have now become essential for diagnostic purposes,
for devising treatment strategies, and for monitoring disease regression and progression …
for devising treatment strategies, and for monitoring disease regression and progression …
Imputation performance in Latin American populations: Improving rare variants representation with the inclusion of native American genomes
Current Genome-Wide Association Studies (GWAS) rely on genotype imputation to increase
statistical power, improve fine-mapping of association signals, and facilitate meta-analyses …
statistical power, improve fine-mapping of association signals, and facilitate meta-analyses …
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the" endemic Burkitt Lymphoma belt"
Populations in sub-Saharan Africa have historically been exposed to intense selection from
chronic infection with falciparum malaria. Interestingly, populations with the highest malaria …
chronic infection with falciparum malaria. Interestingly, populations with the highest malaria …
Rare Genetic Variants of NLRP12 in Admixed Latino-American Children With SARS-CoV-2–Related Multisystem Inflammatory Syndrome
TMM Barreto, RS Souza, RB São Pedro… - The Journal of …, 2024 - academic.oup.com
Multisystem inflammatory syndrome in children (MIS-C) is a rare, potentially fatal
complication of SARS-CoV-2 infection. Genetic defects in inflammation-related pathways …
complication of SARS-CoV-2 infection. Genetic defects in inflammation-related pathways …
Admixture, genetics and complex diseases in Latin Americans and US Hispanics
G Soares-Souza, V Borda, F Kehdy… - Current Genetic …, 2018 - Springer
Abstract Purpose of the Review We review population and epidemiological genetics studies
in Latin Americans and US Hispanics/Latinos, who are product of admixture between …
in Latin Americans and US Hispanics/Latinos, who are product of admixture between …