Bone morphogenetic proteins

T Katagiri, T Watabe - Cold Spring Harbor Perspectives …, 2016 - cshperspectives.cshlp.org
Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Structural biology and evolution of the TGF-β family

AP Hinck, TD Mueller… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …

TGF-β signal transduction

J Massagué - Annual review of biochemistry, 1998 - annualreviews.org
The transforming growth factor β (TGF-β) family of growth factors control the development
and homeostasis of most tissues in metazoan organisms. Work over the past few years has …

TGF-β family signaling in mesenchymal differentiation

I Grafe, S Alexander, JR Peterson… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Bone morphogenetic proteins: a critical review

B Bragdon, O Moseychuk, S Saldanha, D King… - Cellular signalling, 2011 - Elsevier
Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …

Bone morphogenetic proteins

DI Chen, M Zhao, GR Mundy - Growth factors, 2004 - Taylor & Francis
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …

Bone morphogenetic protein receptors and signal transduction

K Miyazono, Y Kamiya, M Morikawa - Journal of biochemistry, 2010 - academic.oup.com
Bone morphogenetic proteins (BMPs) exhibit broad spectra of biological activities in various
tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung …

Bone morphogenetic proteins, their antagonists, and the skeleton

E Canalis, AN Economides, E Gazzerro - Endocrine reviews, 2003 - academic.oup.com
Skeletal homeostasis is determined by systemic hormones and local factors. Bone
morphogenetic proteins (BMP) are unique because they induce the differentiation of …

Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus

H Mira, Z Andreu, H Suh, DC Lie, S Jessberger… - Cell stem cell, 2010 - cell.com
Neural stem cells (NSCs) in the adult hippocampus divide infrequently, and the molecules
that modulate their quiescence are largely unknown. Here, we show that bone …

The bone morphogenetic protein system in mammalian reproduction

S Shimasaki, RK Moore, F Otsuka… - Endocrine …, 2004 - academic.oup.com
Using molecular, cellular, and genetic approaches, recent studies examining the role of the
bone morphogenetic protein (BMP) family of growth factors in the reproductive system have …