[HTML][HTML] Sex differences in PTSD resilience and susceptibility: Challenges for animal models of fear learning

RM Shansky - Neurobiology of stress, 2015 - Elsevier
PTSD occurs in only a small fraction of trauma-exposed individuals, but risk is twice as high
in women as in men. The neurobiological basis for this discrepancy is not known, but the …

Know thy SEFL: Fear sensitization and its relevance to stressor-related disorders

KJ Nishimura, AM Poulos, MR Drew… - … & Biobehavioral Reviews, 2022 - Elsevier
Extreme stress can cause long-lasting changes in affective behavior manifesting in
conditions such as post-traumatic stress disorder (PTSD). Understanding the biological …

Sex differences in fear regulation and reward-seeking behaviors in a fear-safety-reward discrimination task

EM Greiner, I Müller, MR Norris, KH Ng… - Behavioural brain …, 2019 - Elsevier
Reward availability and the potential for danger or safety potently regulate emotion. Despite
women being more likely than men to develop emotion dysregulation disorders, there are …

Dopamine D1 receptor activation rescues extinction impairments in low-estrogen female rats and induces cortical layer-specific activation changes in prefrontal …

CD Rey, J Lipps, RM Shansky - Neuropsychopharmacology, 2014 - nature.com
Post-traumatic stress disorder (PTSD) is twice as common in women as in men; it is a major
public health problem whose neurobiological basis is unknown. In preclinical studies using …

Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior

TN Huynh, AM Krigbaum, JJ Hanna… - Behavioural brain …, 2011 - Elsevier
The experiment examined whether sex differences and the phase of the light cycle modified
how chronic restraint stress influenced anxiety and depressive-like behavior. Rats were …

Susceptibility and resilience to posttraumatic stress disorder–like behaviors in inbred mice

SE Daws, NF Joseph, S Jamieson, ML King… - Biological …, 2017 - Elsevier
Background The limited neurobiological understanding of posttraumatic stress disorder
(PTSD) has been partially attributed to the need for improved animal models. Stress …

Chronic stress disrupts fear extinction and enhances amygdala and hippocampal Fos expression in an animal model of post-traumatic stress disorder

AN Hoffman, NG Lorson, F Sanabria, MF Olive… - Neurobiology of learning …, 2014 - Elsevier
Chronic stress may impose a vulnerability to develop maladaptive fear-related behaviors
after a traumatic event. Whereas previous work found that chronic stress impairs the …

Effects of stress on the structure and function of the medial prefrontal cortex: Insights from animal models

CL Wellman, JL Bollinger, KM Moench - International review of …, 2020 - Elsevier
Stress alters both cognitive and emotional function, and increases risk for a variety of
psychological disorders, such as depression and posttraumatic stress disorder. The …

Sex differences and chronic stress effects on the neural circuitry underlying fear conditioning and extinction

MR Farrell, DR Sengelaub, CL Wellman - Physiology & behavior, 2013 - Elsevier
There are sex differences in the rates of many stress-sensitive psychological disorders such
as posttraumatic stress disorder (PTSD). As medial prefrontal cortex and amygdala are …

On making (and turning adaptive to) maladaptive aversive memories in laboratory rodents

L Gazarini, CAJ Stern, LJ Bertoglio - Neuroscience & Biobehavioral …, 2023 - Elsevier
Fear conditioning and avoidance tasks usually elicit adaptive aversive memories. Traumatic
memories are more intense, generalized, inflexible, and resistant to attenuation via …