Molecular genetics of the human neutrophil antigens

BK Flesch, A Reil - Transfusion Medicine and Hemotherapy, 2018 - karger.com
Summary Background and Objective: Antibodies to human neutrophil antigens (HNAs) have
been implicated in transfusion-related acute lung injury and allo-and autoimmune …

Frequencies of HNA‐1, HNA‐3, HNA‐4, and HNA‐5 in the Danish and Zambian populations determined using a novel TaqMan real time polymerase chain reaction …

KR Nielsen, MD Koelbaek, K Varming, J Baech… - Tissue …, 2012 - Wiley Online Library
In this study, we report a novel real time polymerase chain reaction (Q‐PCR) method using
TaqMan probes for human neutrophil antigens (HNA)‐1,‐3,‐4, and‐5 genotyping. The …

The frequencies of human neutrophil alloantigens among the Japanese population

M Matsuhashi, NH Tsuno, M Kawabata… - Tissue …, 2012 - Wiley Online Library
Human neutrophil antigens (HNAs) play an important role in a variety of clinical conditions
including immune‐mediated neutropenia, non‐hemolytic transfusion reactions, and …

Work‐up in the case of granulocyte antibodies

B Flesch - ISBT Science Series, 2020 - Wiley Online Library
Granulocyte allo‐and autoantibodies have been implicated in a variety of clinical conditions
such as primary and secondary autoimmune neutropenia (AIN), alloimmune neutropenia …

Determination of human neutrophil antigen‐1,‐3,‐4 and‐5 allele frequencies in E nglish C aucasoid blood donors using a multiplex fluorescent DNA‐based assay

SP Cardoso, W Chong, G Lucas, A Green… - Vox …, 2013 - Wiley Online Library
Background and Objectives A number of DNA‐based methods to genotype the alleles
coding for HNA have been described, but all require the separate amplification and analysis …

Human neutrophil antigen genotype and allele frequencies in Iranian blood donors

B Esmaeili, B Bayat, A Alirezaee… - Journal of …, 2022 - Wiley Online Library
Objective. Human neutrophil antigens (HNAs) can be targeted by HNA‐allo antibodies and
cause a variety of clinical conditions such as transfusion‐related acute lung injury (TRALI) …

Phenotyping and genotyping of HNA: prevalence, risk of alloimmunization, and HNA incompatibilities in Indians

H Gogri, M Parihar, S Kulkarni, M Madkaikar… - Transfusion Medicine …, 2023 - karger.com
Background: Antibodies to human neutrophil alloantigens (HNA) are involved in the
pathophysiology of several clinical conditions including transfusion-related acute lung injury …

[HTML][HTML] Genotyping of human neutrophil antigens by polymerase chain reaction sequence-based typing

J He, W Zhang, W Wang, N Chen, Z Han, J He… - Blood …, 2014 - ncbi.nlm.nih.gov
Background Genotyping for human neutrophil antigen (HNA) systems is required in the
investigation of disorders involving alloimmunisation to HNA. We established a polymerase …

Determination of neutrophil antigen HNA‐3a and HNA‐3b genotype frequencies in six racial groups by high‐throughput 5′ exonuclease assay

KL Bowens, MJ Sullivan, BR Curtis - Transfusion, 2012 - Wiley Online Library
BACKGROUND: People with the human neutrophil antigen (HNA)‐3b/3b type can make
HNA‐3a antibodies, which have been reported to cause immune neutropenia disorders and …

Risk estimation of HNA-3 incompatibility and alloimmunization in Thai populations

O Nathalang, K Intharanut, K Siriphanthong… - PLoS …, 2015 - journals.plos.org
Severe transfusion-related acute lung injury (TRALI) is often due to antibodies in blood
components directed against human neutrophil antigen (HNA)-3a. This study aimed to …