To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …

The implications of a tumor microenvironment in cancer initiation and progression have
drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant …

Metabolic reprogramming provides tumors with an energy source and biofuel to support
their survival in the malignant microenvironment. Extensive research into the intrinsic …

Simple Summary Scientists have been working on the development of nanomedicine-based
tumor therapy, rather than conventional treatment, to treat cancer for several years …

Compared to normal tissues, the tumor microenvironment (TME) has a number of aberrant
characteristics including hypoxia, acidosis, and vascular abnormalities. Many researchers …

Over past decades, nanotechnology has contributed to the biomedical field in areas
including detection, diagnosis, and drug delivery via opto-electronic properties or …

Background Cancer-associated fibroblasts (CAFs) represent the predominant stromal
component within the tumour microenvironment (TME), exhibiting considerable …

Simple Summary Despite access to a vast arsenal of anticancer agents, many fail to realise
their full therapeutic potential in clinical practice. One key determinant of this is the evolution …