[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …
The obese adipose tissue microenvironment in cancer development and progression
DF Quail, AJ Dannenberg - Nature Reviews Endocrinology, 2019 - nature.com
Obesity is associated with both increased cancer incidence and progression in multiple
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks …
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature
Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …
[HTML][HTML] The meningeal lymphatic system: a new player in neurophysiology
The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of
particular relevance is its participation in diseases associated with protein accumulation and …
particular relevance is its participation in diseases associated with protein accumulation and …
[HTML][HTML] Lymphatic vessel network structure and physiology
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …
which has the holistic function to maintain the local physiologic environment for every cell in …
Lymphoangiocrine signals promote cardiac growth and repair
Recent studies have suggested that lymphatics help to restore heart function after cardiac
injury,,,,–. Here we report that lymphatics promote cardiac growth, repair and …
injury,,,,–. Here we report that lymphatics promote cardiac growth, repair and …
From sewer to saviour—targeting the lymphatic system to promote drug exposure and activity
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …
Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity
Visceral adipose tissue (VAT) encases mesenteric lymphatic vessels and lymph nodes
through which lymph is transported from the intestine and mesentery. Whether mesenteric …
through which lymph is transported from the intestine and mesentery. Whether mesenteric …
Lymphatic pumping: mechanics, mechanisms and malfunction
JP Scallan, SD Zawieja… - The Journal of …, 2016 - Wiley Online Library
A combination of extrinsic (passive) and intrinsic (active) forces move lymph against a
hydrostatic pressure gradient in most regions of the body. The effectiveness of the lymph …
hydrostatic pressure gradient in most regions of the body. The effectiveness of the lymph …