Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Cysteine protease cathepsins have traditionally been considered as lysosome-restricted
proteases that mediate proteolysis of unwanted proteins. However, studies from the past …

Abstract Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of
adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic …

Abstract Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular
endothelia, where it increases cell membrane water permeability,,. The role of AQP1 in …

Tumors develop through successive stages characterized by changes in gene expression
and protein function. Gene expression profiling of pancreatic islet tumors in a mouse model …

Lysosomes, with their arsenal of degradative enzymes are increasingly becoming an area of
interest in the field of oncology. The changes induced in this compartment upon …

The general view on cysteine cathepsins, which were long believed to be primarily involved
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …

Mast cells contribute importantly to allergic and innate immune responses by releasing
various preformed and newly synthesized mediators,. Previous studies have shown mast …

Atherosclerosis is an inflammatory disease characterized by extensive remodeling of the
extracellular matrix architecture of the arterial wall. Although matrix metalloproteinases and …

Pericellular proteases play an important role in angiogenesis and vasculogenesis. They
comprise (membrane-type) matrix metalloproteinases [(MT-) MMPs], serine proteases …