The Mycobactin biosynthesis pathway: A prospective therapeutic target in the battle against tuberculosis

M Shyam, D Shilkar, H Verma, A Dev… - Journal of Medicinal …, 2020 - ACS Publications
The alarming rise in drug-resistant clinical cases of tuberculosis (TB) has necessitated the
rapid development of newer chemotherapeutic agents with novel mechanisms of action. The …

Natural products against key Mycobacterium tuberculosis enzymatic targets: Emerging opportunities for drug discovery

G Cazzaniga, M Mori, LR Chiarelli, A Gelain… - European journal of …, 2021 - Elsevier
For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

3.08-Furans and their Benzo Derivatives: Applications

BA Keay, JM Hopkins, PW Dibble - … Heterocyclic Chemistry III, 2008 - hero.epa.gov
This chapter provides an overview of literature from 1996 on the applications of various
furan and benzofuran containing compounds. In addition to compounds that contain a furan …

Approaches for targeting the mycobactin biosynthesis pathway for novel anti-tubercular drug discovery: Where we stand

M Shyam, D Shilkar, G Rakshit… - Expert opinion on drug …, 2022 - Taylor & Francis
Introduction Several decades of antitubercular drug discovery efforts have focused on novel
antitubercular chemotherapies. However, recent efforts have greatly shifted toward …

Iron acquisition and metabolism as a promising target for antimicrobials (bottlenecks and opportunities): where do we stand?

G Stelitano, M Cocorullo, M Mori, S Villa… - International Journal of …, 2023 - mdpi.com
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) infections
is one of the most crucial challenges currently faced by the scientific community …

Synthesis and assessment of the in vitro and ex vivo activity of salicylate synthase (Mbti) inhibitors as new candidates for the treatment of mycobacterial infections

M Mori, G Stelitano, A Griego, LR Chiarelli… - Pharmaceuticals, 2022 - mdpi.com
Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most
dangerous infectious diseases worldwide. Because several pathogenic strains of M …

Synthesis and In Vitro and In Vivo Biological Activity Evaluation and Quantitative Proteome Profiling of Oxadiazoles Bearing Flexible Heterocyclic Patterns

QQ Tao, LW Liu, PY Wang, QS Long… - Journal of agricultural …, 2019 - ACS Publications
A novel series of simple 1, 3, 4-oxadiazoles that bear flexible heterocyclic patterns was
prepared, and their biological activities in plant pathogenic bacteria, fungi, oomycetes, and …

Targeting Mycobacterium tuberculosis iron-scavenging tools: A recent update on siderophores inhibitors

G Kumar, PA Adhikrao - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …

Design, synthesis and anti-Mycobacterium tuberculosis evaluation of new thiazolidin-4-one and thiazolo [3, 2-a][1, 3, 5] triazine derivatives

MH Younis, ER Mohammed, AR Mohamed… - Bioorganic …, 2022 - Elsevier
In response to the urgent need to encounter infection diseases, and upon increasing
concerns about the devastating effects of tuberculosis (TB), the promising thiazolidin-4-one …

Target identification in anti-tuberculosis drug discovery

R Capela, R Félix, M Clariano, D Nunes… - International Journal of …, 2023 - mdpi.com
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis (TB), a disease
that, although preventable and curable, remains a global epidemic due to the emergence of …