The role of host genetics in the immune response to SARS‐CoV‐2 and COVID‐19 susceptibility and severity

IG Ovsyannikova, IH Haralambieva… - Immunological …, 2020 - Wiley Online Library
This article provides a review of studies evaluating the role of host (and viral) genetics
(including variation in HLA genes) in the immune response to coronaviruses, as well as the …

SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective

M Sironi, SE Hasnain, B Rosenthal, T Phan… - Infection, genetics and …, 2020 - Elsevier
In less than five months, COVID-19 has spread from a small focus in Wuhan, China, to more
than 5 million people in almost every country in the world, dominating the concern of most …

[HTML][HTML] COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

U Sahin, A Muik, E Derhovanessian, I Vogler, LM Kranz… - Nature, 2020 - nature.com
An effective vaccine is needed to halt the spread of the severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) pandemic. Recently, we reported safety, tolerability and …

[HTML][HTML] Genetic gateways to COVID‐19 infection: implications for risk, severity, and outcomes

M Debnath, M Banerjee, M Berk - The FASEB Journal, 2020 - ncbi.nlm.nih.gov
The dynamics, such as transmission, spatial epidemiology, and clinical course of
Coronavirus Disease‐2019 (COVID‐19) have emerged as the most intriguing features and …

Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology

JS Tregoning, J Schwarze - Clinical microbiology reviews, 2010 - Am Soc Microbiol
In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy,
in particular, is a time of increased disease susceptibility and severity. Early-life viral …

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

CI van der Made, MG Netea, FL van der Veerdonk… - Genome medicine, 2022 - Springer
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights
have been gained into virus biology and the host factors that modulate the human immune …

ACE2, TMPRSS2, and Furin variants and SARS‐CoV‐2 infection in Madrid, Spain

L Torre‐Fuentes, J Matías‐Guiu… - Journal of medical …, 2021 - Wiley Online Library
It has been suggested that some individuals may present genetic susceptibility to SARS‐
CoV‐2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 …

Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis

E Di Maria, A Latini, P Borgiani, G Novelli - Human genomics, 2020 - Springer
The COVID-19 pandemic has strengthened the interest in the biological mechanisms
underlying the complex interplay between infectious agents and the human host. The …

The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)

CL Raison, AH Miller - Molecular psychiatry, 2013 - nature.com
Given the manifold ways that depression impairs Darwinian fitness, the persistence in the
human genome of risk alleles for the disorder remains a much debated mystery …

Concurrent human antibody and TH1 type T-cell responses elicited by a COVID-19 RNA vaccine

U Sahin, A Muik, E Derhovanessian, I Vogler, LM Kranz… - MedRxiv, 2020 - medrxiv.org
An effective vaccine is needed to halt the spread of the SARS-CoV-2 pandemic. Recently,
we reported safety, tolerability and antibody response data from an ongoing placebo …